EC	5.5.1.26
Accepted name:	nogalonic acid methyl ester cyclase
Reaction:	nogalaviketone = methyl nogalonate
Glossary:	methyl nogalonate = methyl [4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate nogalaviketone = methyl 5,7-dihydroxy-2-methyl-4,6,11-trioxo-3,4,6,11-tetrahydrotetracene-1-carboxylate
Other name(s):	methyl nogalonate cyclase; SnoaL (gene name); methyl nogalonate lyase (cyclizing)
Systematic name:	nogalaviketone lyase (ring-opening)
Comments:	The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
References:	1.  Sultana, A., Kallio, P., Jansson, A., Wang, J.S., Niemi, J., Mantsala, P. and Schneider, G. Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation. EMBO J. 23 (2004) 1911–1921. [PMID: 15071504] 2.  Sultana, A., Kallio, P., Jansson, A., Niemi, J., Mantsala, P. and Schneider, G. Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 1118–1120. [PMID: 15159574]
[EC 5.5.1.26 created 2015]